Steglatro contains ertugliflozin for glucose control in adults with type 2 diabetes. It belongs to the SGLT2 inhibitor class, but does not have the broader heart-failure or kidney indications of some other medicines in that class.
The approved uses and formulations described here follow US prescribing information. They may differ in other countries.
| Medicine detail | Details |
|---|---|
| Active ingredient(s) | ertugliflozin |
| Medicine class | SGLT2 inhibitor |
| Forms and strengths | Oral tablets: 5 and 15 mg |
How Steglatro works
Steglatro is used with diet and exercise to improve glucose control in adults with type 2 diabetes. It blocks SGLT2 in the kidneys, increasing the amount of glucose passed in urine.
Source: [1]
Strength and kidney review
Tablets contain 5 or 15 mg and are used once daily. Kidney function affects suitability and glucose-lowering effectiveness. A higher strength does not bypass a kidney restriction, and the prescriber must evaluate the appropriate regimen rather than selecting from a strength list alone.
Source: [1]
Ketoacidosis and fasting
The label warns about ketoacidosis and includes interruption before surgery or prolonged fasting under clinical direction. Ketoacidosis can occur without markedly elevated glucose. Ask the team for the exact interruption and restart plan and for advice during illness or reduced food intake.
Source: [1]
Other precautions
Volume depletion, genital fungal infections, urinary infections and lower-limb amputation are among the warnings. Foot symptoms, hydration and kidney function deserve attention. A serious infection or significant symptoms of ketoacidosis should not be managed by simply waiting for the next routine appointment.
Source: [1]
Ertugliflozin in Segluromet
Segluromet combines ertugliflozin with metformin and has additional restrictions, including a boxed warning for lactic acidosis. When changing to or from the combination, ask the prescriber to check both ingredients and explain which tablets it replaces.
Source: [1]
Questions and answers
Is Steglatro the same as Segluromet?
No. Segluromet adds metformin.
Is Steglatro approved for heart failure?
Its US prescribing information covers glucose control in adults with type 2 diabetes. It does not have the heart-failure indication approved for some other SGLT2 medicines.
Can kidney restrictions be solved by changing tablet strength myself?
No. Kidney function and the regimen require clinical assessment.
Related reading
Sources
Sources checked 1 October 2026. This information does not replace advice from your healthcare professional. For complete warnings and instructions, read the product information and consult the prescribing team.
Reviewed by: Mattias Hagman, PhD
About the reviewer:
Dr Mattias Hagman (PhD, University of Sydney) has an academic background and experience working with healthcare-related content and regulated industries. He has lecturing experience at international universities, including Stockholm University and the University of Malta.
Last reviewed: October 2026