Synjardy combines empagliflozin with metformin. Synjardy and Synjardy XR have different release types, dosing schedules and approved ages.
The approved uses and formulations described here follow US prescribing information. They may differ in other countries.
| Medicine detail | Details |
|---|---|
| Active ingredient(s) | empagliflozin / metformin hydrochloride |
| Medicine class | SGLT2 inhibitor / biguanide combination |
| Forms and strengths | Synjardy immediate release and Synjardy XR; paired strengths vary by release type |
Current indication and age distinctions
The current US label includes glucose control from age 10 for immediate-release Synjardy; Synjardy XR’s glucose-control indication is for adults. It also describes specified adult cardiovascular, heart-failure and kidney benefits of empagliflozin within the combination, limited to adults with type 2 diabetes because it contains metformin.
Source: [1]
Release type controls the regimen
Immediate-release strengths include 5/500, 5/1000, 12.5/500 and 12.5/1000 mg and are taken twice daily with meals. XR strengths include 5/1000, 10/1000, 12.5/1000 and 25/1000 mg with once-daily morning administration. Prescribed tablet count still matters; do not infer it solely from frequency.
Source: [1]
Metformin-specific safety
The combination has a boxed warning for lactic acidosis and kidney-based restrictions. Contrast procedures, acute illness and alcohol can be relevant. The clinical team should provide instructions for interruption and restart where needed, accounting for both metformin and empagliflozin.
Source: [1]
Empagliflozin-specific risks
Ketoacidosis, volume depletion and genital or urinary infections are important precautions. Ketoacidosis can occur without very high glucose. Discuss hydration, kidney function and any planned fasting or procedure with the team rather than treating the combination as an ordinary metformin tablet.
Source: [1]
Related brands and duplicate ingredients
Jardiance contains empagliflozin alone; Glyxambi combines it with linagliptin rather than metformin. Tell the prescriber about any of these medicines or separate metformin tablets before starting Synjardy. Unlike some Jardiance uses, Synjardy’s approved uses are limited to people with type 2 diabetes.
Source: [1]
Questions and answers
Does Synjardy XR have the same age labeling as Synjardy?
No. Immediate-release Synjardy is approved for glucose control from age 10, while Synjardy XR is approved for adults.
Does Synjardy contain linagliptin?
No. That ingredient is in Glyxambi; Synjardy contains empagliflozin and metformin.
Can Synjardy be prescribed for the same people as Jardiance?
Not in every case. Synjardy contains metformin, and its approved uses are limited to people with type 2 diabetes. Some Jardiance uses include adults without diabetes.
Related reading
Sources
Sources checked 1 October 2026. This information does not replace advice from your healthcare professional. For complete warnings and instructions, read the product information and consult the prescribing team.
Reviewed by: Mattias Hagman, PhD
About the reviewer:
Dr Mattias Hagman (PhD, University of Sydney) has an academic background and experience working with healthcare-related content and regulated industries. He has lecturing experience at international universities, including Stockholm University and the University of Malta.
Last reviewed: October 2026